The production of "Spider-Man: No Way Home" was the result of a complex agreement between Marvel Studios and Sony Pictures. Even before the first film with Tom Holland, there were plans for a trilogy. After initial difficulties in the collaboration, both studios were able to agree on a new deal in September 2019, which saw Kevin Feige and Amy Pascal as producers and ensured that the film became part of the Marvel Cinematic Universe (MCU).

Chris McKenna and Erik Sommers, who had already written the scripts for the previous films, returned, and Jon Watts once again took over as director. In addition to the well-known actors Tom Holland, Zendaya and Jacob Batalon, Jamie Foxx as Electro and Alfred Molina as Dr. Octopus also returned to their roles from previous Spider-Man films.

A particular surprise was the involvement of Andrew Garfield and Tobey Maguire, who reprised their respective incarnations of Spider-Man from previous film series. The film was mainly shot at Trilith Studios and Tyler Perry Studios in Atlanta, with Mauro Fiore directing the camera.

The theatrical release was postponed several times due to the COVID-19 pandemic, but finally took place in December 2021. The film was a huge commercial success. It grossed USD 260 million in the United States alone on its first weekend and exceeded the USD 1 billion mark in international revenue just twelve days after its premiere. By the end of April 2022, worldwide revenue amounted to around 1.9 billion US dollars, making it one of the most successful films of all time.