Having acquired the Power Stone, Thanos and his lieutenants intercept the spaceship carrying the survivors of Asgard's destruction. After subduing Thor, Thanos extracts the Space Stone from the Tesseract, overpowers the Hulk, and kills Loki. Thanos sends Hulk to Earth using the Bifröst.
Hulk crash-lands in the Sanctum Sanctorum in New York City, reverting to the form of Bruce Banner. He warns Stephen Strange and Wong about Thanos's plan to destroy half of all life in the universe.
The Guardians of the Galaxy respond to the Asgardian ship's distress call and rescue Thor. Thor surmises that Thanos is after the Reality Stone, which Taneleer Tivan possesses on Knowhere. He travels with Rocket and Groot to Nidavellir to enlist the dwarf king Eitri's aid in creating the battle-axe Stormbreaker. Peter Quill, Gamora, Drax, and Mantis travel to Knowhere, finding Thanos already has the Reality Stone. Thanos kidnaps Gamora, who discloses the Soul Stone's location to save Nebula from torture. On Vormir, the Stone's keeper, Red Skull, tells Thanos that he can only acquire it by sacrificing someone he loves.
In Edinburgh, Midnight and Glaive ambush Wanda Maximoff and Vision to retrieve the Mind Stone in Vision's forehead. Steve Rogers, Natasha Romanoff, and Sam Wilson rescue them and they take shelter with James Rhodes and Banner at the Avengers Compound. Vision asks Wanda to destroy him and the Mind Stone to keep it from Thanos, but Wanda refuses. Rogers suggests they travel to Wakanda, which he believes has the resources to remove the Stone without killing Vision.
Nebula escapes captivity and asks the remaining Guardians to meet her on Thanos's destroyed homeworld, Titan. Stark and Parker kill Maw and rescue Strange. The trio crash-lands on Titan, where they meet Quill, Drax, and Mantis. Using the Time Stone, Strange views millions of possible futures, seeing only one in which the Avengers win. The group formulates a plan to subdue Thanos and remove the Infinity Gauntlet, with which he safely houses and wields the Stones. Thanos appears, justifying his plans as necessary to guarantee the survival of an overpopulated universe. Thanos grievously wounds Stark, but Strange offers the Time Stone in exchange for sparing Stark's life.
In Wakanda, Rogers reunites with Bucky Barnes before Thanos' army invades. The Avengers, along with T'Challa and the Wakandan forces, mount a defense while Shuri works to extract the Mind Stone from Vision. Unable to summon the Hulk after losing to Thanos, Banner fights in Stark's Hulkbuster armor. Thor, Rocket, and Groot arrive to reinforce the Avengers. Shuri cannot complete the extraction before Thanos himself arrives on the field, slowed only briefly by Banner, Rogers, T'Challa, Wilson, Rhodes, Barnes, Okoye, Romanoff, and Groot. Vision convinces a reluctant Wanda to destroy him and the Mind Stone, but Thanos uses the Time Stone to reverse her actions, rip the stone from Vision's forehead, and complete the Gauntlet. Although Thor severely wounds Thanos with Stormbreaker, Thanos activates the completed Gauntlet by snapping his fingers before teleporting away.
Half of all life across the universe disintegrates and Thanos has won the battle.
- Robert Downey Jr.Tony Stark / Iron Man
- Chris EvansSteve Rogers / Captain America
- Chris HemsworthThor Odinson
- Mark RuffaloBruce Banner / The Hulk
- Elizabeth OlsenWanda Maximoff / Scarlet Witch
- Sebastian StanJames 'Bucky' Barnes / Winter Soldier
- Benedict CumberbatchStephen Strange / Doctor Strange
- Paul BettanyVision
- Josh BrolinThanos
- Chris PrattPeter Quill / Star-Lord
- Zoe SaldanaGamora
- Bradley CooperRocket Raccoon
- Vin DieselGroot
- Dave BautistaDrax
- Karen GillanNebula
- Scarlett JohanssonNatasha Romanoff / Black Widow
- Tom HiddlestonLoki
- Tom HollandPeter Parker / Spider-Man
- Chadwick BosemanT'Challa / Black Panther
- Tom Vaughan-LawlorEbony Maw