After Molly (Michelle Williams) is diagnosed with terminal breast cancer, she decides to leave her husband Steve (Jay Duplass). For the first time in her life, she explores her intimate desires in all their depth and complexity.

Brace yourselves! Molly has a lot on her mind - and little time. There's no room for indignation or judgment, Molly doesn't care what you think about her "bucket list" (a term that only elicits an annoyed eye roll from her, by the way). Her best friend Nikki (Jenny Slate) gives her the courage for this adventure - a woman with so much devotion and love that you immediately want to pick up the phone and call your own best friend.